LOL, organs can be extremely varied, and just like guitars, it also matters greatly what kind of amp and speaker you run them through. Magnus's are definitely low on the totem pole, but even B3s can sound bland and characterless if they're not played through good amps and played well. Obviously the Leslie rotary speaker is a good match, but I also love the Jon Lord style of running them through an overdriven Marshall, too. But most transistor organs like the Magnus, Vox Continental, and Farfisa are pretty tacky sounding by nature. I can't understand why Ray Manzura insisted on playing the Farfisa, he was a great musician by anyone's standard, but jesus so many of those songs would have sounded even better with a B3.
But similarly, the guitar or guitar sim is only part of the equation, the biggest part to the sound is A) how it's played, and B) what kind of amp and settings it's going through. Def Leopard isn't exactly metal, so it's probably not gonna have as severe muting as Maiden or particularly like modern metal, but it's still gonna be there. But it's also good to have a VI or patch that has multiple samples of the same note, so that when you're repeating a note (which is something hard rock/metal guitar parts do a lot), they all sound slightly different. The amp is really important. Lead sounds often have far more gain and distortion, which makes them sustain longer and be even flatter in tone. I've commonly used Orange Tree Strawberry Electric for lead guitars, because that's more it's focus. However, Shreddage 2 (I only have Shreddage 1) sounds even more organic to my ears, and I'm thinking of upgrading and switching over to using it 100% of the time. But you're going to want to have a good amp sim too. I use Guitar Rig because I have NI Komplete, but there are better out there. Amplitube and Bias Positive Grid are both really highly regarded.
